Browsing by Contributors Coombes, RC

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PreviewIssue DateTitleContributor(s)
23-Sep-2015Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cellsFilipovic, A; Lombardo, Y; Fronato, M; Abrahams, J; Aboagye, E; Quang-De, N; d'Aqua, BB; Ridley, A; Green, A; Rahka, E; Ellis, I; Recchi, C; Przulj, N; Sarajlic, A; Alattia, J-R; Fraering, P; Deonarain, M; Coombes, RC
14-Oct-2015APOBEC3B mediated cytidine deamination is required for estrogen receptor action in breast cancerAli, S; Periyasamy, M; Patel, H; Lai, C-F; Nguyen, VTM; Nevedomskaya, E; Harrod, A; Russell, R; Remenyi, J; Ochocka, AM; Thomas, RS; Fuller-Pace, F; Gyorffy, B; Caldas, C; Navaratnam, N; Carroll, JS; Zwart, W; Coombes, RC; Magnani, L; Buluwela, L; Ali, S
28-Apr-2016Apoptosis inhibitor TRIAP1 is a novel effector of drug resistanceBreast Cancer Research Trust; Breast Cancer Campaign; Adams, C; Cazzanelli, G; Rasul, S; Hitchinson, B; Hu, Y; Coombes, RC; Raguz, S; Yaguee, E
12-May-2016Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trialsDowsett, M; Forbes, JF; Bradley, R; Ingle, J; Aihara, T; Bliss, J; Boccardo, F; Coates, A; Coombes, RC; Cuzick, J; Dubsky, P; Gnant, M; Kaufmann, M; Kilburn, L; Perrone, F; Rea, D; Thuerlimann, B; Van de Velde, C; Pan, H; Peto, R; Davies, C; Gray, R; Baum, M; Buzdar, A; Cuzick, J; Dowsett, M; Forbes, JF; Sestak, I; Markopoulos, C; Dubsky, P; Fesl, C; Gnant, M; Jakesz, R; Coates, A; Colleoni, M; Forbes, JF; Gelber, R; Regan, M; Kaufmann, M; Von Minckwitz, G; Bliss, J; Coates, A; Coombes, RC; Forbes, JF; Kilburn, L; Snowdon, C; Boccardo, F; Perrone, F; Goss, P; Ingle, J; Pritchard, K; Anderson, S; Costantino, J; Mamounas, E; Aihara, T; Ohashi, Y; Watanabe, T; Bastiaannet, E; Van de Velde, C; Rea, D
12-May-2016Bone marrow micrometastases in early breast cancer–30-year outcomeMansi, J; Morden, J; Bliss, JM; Neville, M; Coombes, RC
22-Jun-2016CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor- positive breast cancerPatel, H; Abduljabbar, R; Lai, CF; Periyasamy, M; Harrod, A; Gemma, C; Steel, J; Patel, N; Busonero, C; Jerjees, D; Remenyi, J; Smith, S; Gomm, JJ; Magnani, L; Gyorffy, B; Jones, JL; Fuller-Pace, FV; Shousha, S; Buluwela, L; Rakha, EA; Ellis, IO; Coombes, RC; Ali, S
18-Nov-2014CK1 modulates the transcriptional activity of ER via AIB1 in an estrogen-dependent manner and regulates ERAIB1 interactionsGiamas, G; Castellano, L; Feng, Q; Knippschild, U; Jacob, J; Thomas, RS; Coombes, RC; Smith, CL; Jiao, LR; Stebbing, J
18-Nov-2014CK1 modulates the transcriptional activity of ER via AIB1 in an estrogen-dependent manner and regulates ERAIB1 interactionsGiamas, G; Castellano, L; Feng, Q; Knippschild, U; Jacob, J; Thomas, RS; Coombes, RC; Smith, CL; Jiao, LR; Stebbing, J
9-Feb-2015Co-regulated gene expression by oestrogen receptor alpha and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cellsLai, C-F; Flach, KD; Alexi, X; Fox, SP; Ottaviani, S; Thiruchelvam, PTR; Kyle, FJ; Thomas, RS; Launchbury, R; Hua, H; Callaghan, HB; Carroll, JS; Coombes, RC; Zwart, W; Buluwela, L; Ali, S
9-Feb-2015Co-regulated gene expression by oestrogen receptor alpha and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cellsLai, C-F; Flach, KD; Alexi, X; Fox, SP; Ottaviani, S; Thiruchelvam, PTR; Kyle, FJ; Thomas, RS; Launchbury, R; Hua, H; Callaghan, HB; Carroll, JS; Coombes, RC; Zwart, W; Buluwela, L; Ali, S
8-May-2015Detection of HER2 amplification in circulating free DNA in patients with breast cancerPage, K; Hava, N; Ward, B; Brown, J; Guttery, DS; Ruangpratheep, C; Blighe, K; Sharma, A; Walker, RA; Coombes, RC; Shaw, JA
8-May-2015Detection of HER2 amplification in circulating free DNA in patients with breast cancerPage, K; Hava, N; Ward, B; Brown, J; Guttery, DS; Ruangpratheep, C; Blighe, K; Sharma, A; Walker, RA; Coombes, RC; Shaw, JA
8-Jun-2016Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistanceKaliszczak, M; Patel, H; Kroll, SHB; Carroll, L; Smith, G; Delaney, S; Heathcote, DA; Bondke, A; Fuchter, MJ; Coombes, RC; Barrett, AGM; Ali, S; Aboagye, EO
21-Jun-2016Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasionBreast Cancer Campaign and Breakthrough Breast Cancer; Nguyen, VTM; Barozzi, I; Faronato, M; Lombardo, Y; Steel, JH; Patel, N; Darbre, P; Castellano, L; Gyorffy, B; Woodley, L; Meira, A; Patten, DL; Vircillo, V; Periyasamy, M; Ali, S; Frige, G; Minucci, S; Coombes, RC; Magnani, L
27-May-2015DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activationFaronato, M; Nguyen, VTM; Patten, DK; Lombardo, Y; Steel, JH; Patel, N; Woodley, L; Shousha, S; Coombes, RC; Magnani, LM
7-Jun-2016Expression of CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor positive breast cancerBreast Cancer Now; Cancer Research Technology Ltd; Patel, H; Abduljabbar, R; Chun-Fui, L; Periyasamy, M; Harrod, A; Gemma, C; Steel, JH; Patel, N; Busonero, C; Jerjees, D; Remenyi, J; Smith, S; Gomm, JJ; Magnani, L; Győrffy, B; Jones, LJ; Fuller-Pace, F; Shousha, S; Buluwela, L; Rakha, EA; Ellis, IO; Coombes, RC; Ali, S
4-Nov-2015Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancerLin, M-L; Patel, H; Remenyi, J; Banerji, CRS; Lai, C-F; Periyasamy, M; Lombardo, Y; Busonero, C; Ottaviani, S; Passey, A; Quinlan, PR; Purdie, CA; Jordan, LB; Thompson, AM; Finn, RS; Rueda, OM; Caldas, C; Gil, J; Coombes, RC; Fuller-Pace, FV; Teschendorff, AE; Buluwela, L; Ali, S
22-Aug-2016FOXM1 is a transcriptional target of ERα and has a critical role in breast cancer endocrine sensitivity and resistanceMillour, J; Constantinidou, D; Stavropoulou, AV; Wilson, MSC; Myatt, SS; Kwok, JM-M; Sivanandan, K; Coombes, RC; Medema, RH; Hartman, J; Lykkesfeldt, AE; Lam, EW-F
22-Aug-2016FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistanceKhongkow, P; Karunarathna, U; Khongkow, M; Gong, C; Gomes, AR; Yague, E; Monteiro, LJ; Kongsema, M; Zona, S; Man, EPS; Tsang, JW-H; Coombes, RC; Wu, K-J; Khoo, U-S; Medema, RH; Freire, R; Lam, EW-F
2-Sep-2016Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancerHarrod, A; Fulton, J; Nguyen, VTM; Periyasamy, M; Ramos Garcia, L; Lai, C-F; Metodieva, G; De Giorgio, A; Williams, RL; Santos, DB; Jimenez Gomez, P; Lin, M-L; Metodiev, MV; Stebbing, J; Castellano, L; Magnani, L; Coombes, RC; Buluwela, L; Ali, S