Please use this identifier to cite or link to this item: http://192.168.1.35:80/jspui/handle/Hannan/32353
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dc.contributorDepartment of Health-
dc.contributorNational Institute for Health Research Health Technology Assessment Programme-
dc.contributor.authorDrewe, CJ-
dc.contributor.authorParker, LP-
dc.contributor.authorKelsey, LJ-
dc.contributor.authorNorman, PE-
dc.contributor.authorPowell, JT-
dc.contributor.authorDoyle, BJ-
dc.date2018-07-26T06:00:43Z-
dc.date2017-07-26-
dc.date2017-06-16-
dc.date.accessioned2019-05-15T09:53:07Z-
dc.date.available2019-05-15T09:53:07Z-
dc.date.issued2017-11-08T11:21:52Z-
dc.identifier0021-9290-
dc.identifierhttps://dx.doi.org/10.1016/j.jbiomech.2017.06.029-
dc.identifier07/37/64-
dc.identifierHTA project 07/37/64-
dc.identifier.urihttps://spiral.imperial.ac.uk:8443/handle/10044/1/53210-
dc.identifier.urihttp://localhost/handle/Hannan/32353-
dc.descriptionOur knowledge of how geometry influences abdominal aortic aneurysm (AAA) biomechanics is still developing. Both iliac bifurcation angle and proximal neck angle could impact the haemodynamics and stresses within AAA. Recent comparisons of the morphology of ruptured and intact AAA show that cases with large iliac bifurcation angles are less likely to rupture than those with smaller angles. We aimed to perform fluid-structure interaction (FSI) simulations on a range of idealised AAA geometries to conclusively determine the influence of proximal neck and iliac bifurcation angle on AAA wall stress and haemodynamics. Peak wall shear stress (WSS) and time-averaged WSS (TAWSS) in the AAA sac region only increased when the proximal neck angle exceeded 30°. Both peak WSS (p < 0.0001) and peak von Mises wall stress (p = 0.027) increased with iliac bifurcation angle, whereas endothelial cell activation potential (ECAP) decreased with iliac bifurcation angle (p < 0.001) and increased with increasing neck angle. These observations may be important as AAAs have been shown to expand, develop thrombus and rupture in areas of low WSS. Here we show that AAAs with larger iliac bifurcation angles have higher WSS, potentially reducing the likelihood of rupture. Furthermore, ECAP was lower in AAA geometries with larger iliac bifurcation angles, implying less likelihood of thrombus development and wall degeneration. Therefore our findings could help explain the clinical observation of lower rupture rates associated with AAAs with large iliac bifurcation angles.-
dc.languageEnglish-
dc.publisherElsevier-
dc.relationJournal of Biomechanics-
dc.rights© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.source156-
dc.source150-
dc.subjectScience & Technology-
dc.subjectLife Sciences & Biomedicine-
dc.subjectTechnology-
dc.subjectBiophysics-
dc.subjectEngineering, Biomedical-
dc.subjectEngineering-
dc.subjectAbdominal aortic aneurysm-
dc.subjectGeometry-
dc.subjectWall stress-
dc.subjectWall shear stress-
dc.subjectFluid structure interaction-
dc.subjectWALL STRESS-
dc.subjectDIAMETER-
dc.subjectRUPTURE-
dc.subjectRISK-
dc.subjectAbdominal aortic aneurysm-
dc.subjectFluid structure interaction-
dc.subjectGeometry-
dc.subjectWall shear stress-
dc.subjectWall stress-
dc.subjectScience & Technology-
dc.subjectLife Sciences & Biomedicine-
dc.subjectTechnology-
dc.subjectBiophysics-
dc.subjectEngineering, Biomedical-
dc.subjectEngineering-
dc.subjectAbdominal aortic aneurysm-
dc.subjectGeometry-
dc.subjectWall stress-
dc.subjectWall shear stress-
dc.subjectFluid structure interaction-
dc.subjectWALL STRESS-
dc.subjectDIAMETER-
dc.subjectRUPTURE-
dc.subjectRISK-
dc.subject0903 Biomedical Engineering-
dc.subject1106 Human Movement And Sports Science-
dc.subject0913 Mechanical Engineering-
dc.subjectBiomedical Engineering-
dc.titleHaemodynamics and stresses in abdominal aortic aneurysms: A fluid-structure interaction study into the effect of proximal neck and iliac bifurcation angle-
dc.typeArticle-
Appears in Collections:Department of Surgery and Cancer

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