Please use this identifier to cite or link to this item: http://192.168.1.35:80/jspui/handle/Hannan/32359
Title: Pre-operative serum VCAM-1 as a biomarker of atrial fibrillation after coronary artery bypass grafting
Authors: Wellcome Trust;Harling, L;Athanasiou, T;Ashrafian, H;Darzi, A;Gooderham, N;Lambert, J
subject: Biomarker
Post operative atrial fibrillation
Surgery
VCAM-1
Vascular cell adhesion molecule
Clinical Sciences
Respiratory System
Year: 7-Sep-2017
Publisher: BioMed Central
Description: Objective Systemic inflammation is a recognised contributory factor in the pathogenesis of de novo post-operative atrial fibrillation after cardiac surgery. This study aims to determine whether serum soluble vascular endothelial cell adhesion molecule (sVCAM-1) may predict the onset of POAF in patients under going coronary artery bypass grafting. Methods 34 patients undergoing non-emergent, on-pump CABG were prospectively recruited. Plasma was obtained at 24 h pre-operatively and at 48 and 96 h post-operatively. POAF was defined by continuous Holter recording. Inter-group comparisons were performed using student t-test or ANOVA as appropriate. Results Thirteen (13/34) patients developed POAF at a mean of 2.5 days post-operatively. Serum sVCAM-1 was significantly increased in the pre-operative serum of POAF when compared to non-POAF patients (p = 0.022). No significant difference was observed between the groups at 48 h (p = 0.073) or 96 h (p = 0.135) post-operatively. sVCAM-1 had a sensitivity of 60.0% and specificity of 77.27%, with an overall diagnostic accuracy of 75.2% in predicting POAF. Conclusions sVCAM-1 concentration in the pre-operative serum of patients undergoing CABG may accurately predict the onset of de novo POAF. As such, serum sVCAM-1 may be used as a predictive biomarker for this common arrhythmia. Further work must now perform prospective, targeted validation of these results in a larger patient cohort.
URI: https://spiral.imperial.ac.uk:8443/handle/10044/1/50325
http://localhost/handle/Hannan/32359
Standard no: 1749-8090
https://dx.doi.org/10.1186/s13019-017-0632-2
100023/Z/12/Z
Type Of Material: Article
Appears in Collections:Department of Surgery and Cancer

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